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Immune System Function, Conditions & Disorders
Your immune system is a network of organs, white blood cells, proteins and chemicals that work together to protect you from invaders (like germs) that can harm you.

Immune system - Wikipedia
Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli. The adaptive immune system provides a tailored response to each stimulus by learning to recognize molecules it has previously encountered.

Immune system | Description, Function, Innate Immunity, Adaptive ...
The immune system is a group of defense responses found in humans and other advanced vertebrates that helps repel disease-causing entities. Immunity from disease is conferred by two cooperative systems: innate immunity and acquired (or adaptive) immunity.

The immune system: Cells, tissues, function, and disease
The immune system defends the body from invaders such as viruses, bacteria, and foreign bodies. Find out how it works, what can go wrong, and how to boost immune health.

The Immune System - Johns Hopkins Medicine
The immune system works to keep germs and other foreign substances out of the body and destroy any that get in. It's made up of a complicated network of cells and organs.

Overview of the Immune System - National Institute of Allergy and ...
The overall function of the immune system is to prevent or limit infection. All immune cells come from precursors in the bone marrow and develop into mature cells through a series of changes that can occur in different parts of the body.

Immune system - healthdirect
Your immune system recognises 'invaders' such as bacteria, viruses and fungi, as well as abnormal cells like cancer cells, and then helps your body fight them. Your immune system includes the skin, bone marrow, thymus, lymphatic system, lymph nodes, spleen and mucous membranes.

Immune System and Disorders | Autoimmune Disease | MedlinePlus
Your immune system is made up of cells, tissues, and organs that fight infections and diseases. Learn how it works, and about diseases of the immune system.

What is the Immune System? How Your Body’s Defense Works to Keep You Alive
The immune system is a vast, interconnected network of organs, cells, and molecules that protects your body from harmful substances, pathogens (like bacteria, viruses, and fungi), and abnormal cells (such as cancer).

Immune System - Harvard University
From fending off the common cold to attacking cancer cells, the immune system is an incredibly complicated and crucial part of our survival. Each time it mounts a response, the immune system must quickly and carefully orchestrate communication across vast numbers of cells and molecules.

* Rheumatology101 News Today

          News Filter: "immune-system"

HPV: 5 Things All Women Should Know  Johns Hopkins Medicine
We Asked a Doctor If Vitamin D Can Really Support Your Immune System  Verywell Health
Dear Doctor: What to know about shingles, long COVID vaccines, and rebuilding your immune system  SILive.com
Flesh-eating bacteria puts liver disease, immune compromised patients at risk  NewsNation
What doctors want patients to know about strep throat  American Medical Association | AMA
Understanding the Dangers of Pneumonia for Individuals who are Immunocompromised  American Lung Association
Investigational Pancreatic Cancer Vaccine Shows Lasting Results in Early Trial, Supporting Continued Testing  Memorial Sloan Kettering Cancer Center
Can too many vaccines overwhelm the immune system? Physician Dr Amit Prakash Singh explains and debunks other myths | Health  Hindustan Times
7 Secret Ways Doctors Boost Their Immune Systems  The Healthy @Reader's Digest
Nutritional Supplements, Vitamins & Boosting Your Child’s Immunity  HealthyChildren.org
Can our brain talk to our immune system?  Harvard Health
Your immune system has an age of its own: Doctors explain how to tell if it's ageing faster than you are, and what you can do about it  The Times of India
Dear Doctor: What makes some people more reactive to mosquito bites than others?  OregonLive.com
Why vitamin supplements are (probably) a waste of money, according to a Harvard doctor  BBC Science Focus Magazine
Primary Immunodeficiency: What Parents Should Know  WebMD

Common Rheumatological Symptoms

Joint Pain (Arthralgia) — Persistent discomfort or soreness in one or more joints caused by inflammation, wear and tear, or underlying autoimmune responses.
Morning Stiffness — Reduced joint mobility and tightness upon waking, often lasting over 30 to 60 minutes in inflammatory conditions like rheumatoid arthritis.
Joint Swelling and Edema — Visible enlargement of affected joints resulting from fluid accumulation in the synovial membrane and inflamed surrounding tissue.
Localized Warmth and Redness — Elevated temperature and erythema skin discoloration surrounding inflamed joints due to increased blood flow from localized inflammation.
Systemic Fatigue — Overwhelming exhaustion and lack of energy caused by ongoing chronic inflammatory cytokine activity throughout the body.
Raynaud's Phenomenon — Temporary color changes in fingers or toes turning white, blue, and red in response to cold or stress due to vascular spasms.
Malar or Butterfly Rash — Red or purplish facial rash spanning across the bridge of the nose and cheeks, classically associated with systemic lupus erythematosus.

Milestones in Rheumatology History

c. 400 BC: Hippocratic Corpus Coining — Hippocrates uses the term "rheuma" to describe body humors flowing into joints, establishing the early classical concept of joint inflammation.
1592: Formal Definition of Rheumatism — French physician Guillaume de Baillou introduces the modern term "rheumatism" to distinguish systemic acute arthritis from localized gout.
1800: Clinical Description of Rheumatoid Arthritis — Augustin Jacob Landré-Beauvais publishes the first detailed clinical description separating rheumatoid arthritis from gout, calling it "asthenic gout."
1859: Naming of Rheumatoid Arthritis — Sir Alfred Baring Garrod formally coins the term "rheumatoid arthritis" to clearly differentiate the inflammatory autoimmune condition from osteoarthritis and gout.
1940: Discovery of the Rheumatoid Factor — Erik Waaler discovers autoantibodies in the blood of patients with rheumatoid arthritis, laying the groundwork for serological autoimmune diagnostics.
1948: Introduction of Corticosteroid Therapy — Philip Hench and Edward Kendall demonstrate the dramatic anti-inflammatory effects of Compound E (cortisone) in treating rheumatoid arthritis, earning the Nobel Prize.
1998: Emergence of Biologic DMARDs — The FDA approves the first TNF-alpha inhibitors, ushering in the modern era of targeted biologic therapies for autoimmune rheumatic diseases.

Current Trends in Rheumatology Research

Chimeric Antigen Receptor (CAR) T-Cell Reset Therapy — Investigating engineered cellular therapies to achieve drug-free, durable clinical remissions by completely depleting pathogenic autoantibodies in severe refractory lupus and systemic sclerosis.
Selective TYK2 and Oral JAK Pathway Inhibition — Developing highly targeted, small-molecule oral inhibitors like deucravacitinib that disrupt specific cytokine signaling pathways while minimizing broader off-target side effects.
Targeted Pathogenic T-Cell and B-Cell Depletion — Evaluating novel biologics, such as rosnilimab and ianalumab, designed to selectively deplete overactive immune cell subpopulations involved in rheumatoid arthritis and Sjögren's disease.
Biomarker-Driven Precision Medicine — Utilizing pharmacogenomics and molecular biomarkers to predict individualized therapeutic responses and match systemic autoimmune conditions to specific biological mechanisms.
Subclinical Interception and Disease Prevention — Identifying seropositive individuals early using high-risk autoantibody profiles to initiate preventive targeted therapies before irreversible joint damage occurs.
Artificial Intelligence and Predictive Disease Modeling — Deploying machine learning algorithms across electronic health records and imaging modalities to forecast inflammatory flares and refine diagnostic accuracy.