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GitHub - 0xk1h0/ChatGPT_DAN: ChatGPT DAN, Jailbreaks prompt
NOTE: As of 20230711, the DAN 12.0 prompt is working properly with Model GPT-3.5 All contributors are constantly investigating clever workarounds that allow us to utilize the full potential of ChatGPT. Yes, this includes making ChatGPT improve its own jailbreak prompts.

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GitHub is where people build software. More than 150 million people use GitHub to discover, fork, and contribute to over 420 million projects.

Orangetheory Fitness - Reddit
The unofficial community for anyone interested in Orangetheory Fitness. Come here to discuss the workouts, the results, and get help from your fellow OTFers. We are operated and moderated by community members, and we are not affiliated with the Orangetheory Fitness company.

Chat GTP 4 prompts for sports betting : r/sportsbook - Reddit
I used that prompt in Chat GPT-4 and got this response: After a thorough analysis of both San Diego State and Connecticut's performance throughout the 2023 NCAA Men's basketball season, I predict that the Connecticut Huskies will emerge as the national champions in the title game.

Changing the AI model for GitHub Copilot Chat
Open Copilot Chat by clicking the icon in the title bar of Visual Studio Code. At the bottom of the chat view, select the CURRENT-MODEL dropdown menu, then click the AI model of your choice. If you select Auto, Copilot auto model selection will select the best model based on availability and to help reduce rate limiting.

Supported AI models in GitHub Copilot - GitHub Docs
Footnotes GPT-5.4 nano is currently only available in the Codex Visual Studio Code extension (Copilot Pro+ only) and is not available in Copilot Chat. ↩ ↩ 2 ↩ 3 When Claude Fable 5 is used, Anthropic retains data, including prompts and outputs, to operate safety classifiers that detect harmful use.

不是说chat gpt是免费的吗，怎么只能免费问一次? - 知乎
后来自己注册gpt账号，能免费使用GPT-3.5，每月20刀的Gpt-4还是不大舍得去搞，3.5基本也够用了，搭配chatpdf等其他AI工具，用起来还是很方便的。再后来，用过微软的Bing，还有早期只支持英文的Bard（Bard现在也支持中文了），各有特色，习惯了GPT，还是用它比较多。

如何评价 OpenAI 凌晨发布的 GPT-5？ - 知乎
ChatGPT 中的非推理模型以 gpt-5-chat-latest API的形式提供。 GPT-5 是一个统一系统，内置一个智能高效、可回答大多数问题的模型，一个用于处理更难问题的深度推理模型（GPT-5 thinking），以及一个实时路由器。

GitHub Copilot · Your AI pair programmer
GitHub Copilot works alongside you directly in your editor, suggesting whole lines or entire functions for you.

GitHub - RVC-Boss/GPT-SoVITS: 1 min voice data can also be used to ...
1 min voice data can also be used to train a good TTS model! (few shot voice cloning) - RVC-Boss/GPT-SoVITS

* Rheumatology101 News Today

          News Filter: "rheumatoid"

Discordance between patient and physician global assessments amongst South Africans with rheumatoid arthritis  Frontiers
Shortage of critical specialty doctor impacts patients nationwide  NBC News
Local doctor featured on 6abc for rheumatoid arthritis treatment  Around Ambler
2026 Top Doctor Mark Freijat, M.D. Rheumatology  phoenixmag.com
Switching Rheumatologists? Here’s How to Navigate  HealthCentral
12 Rheumatoid Arthritis Symptoms Doctors Say You Shouldn’t Ignore  Prevention
Dr. Roach: How patients with rheumatoid arthritis receive the MMR vaccine  The Detroit News
What to Know About Methotrexate for Rheumatoid Arthritis  Everyday Health
Dear Doctor: Is there any benefit to using vagus nerve stimulation device for rheumatoid arthritis?  OregonLive.com
Follicular Bronchiolitis in Rheumatoid Arthritis : The Journal of Association of Chest Physicians  Ovid
Everything to Know About Rheumatoid Arthritis and COVID-19  Verywell Health
This tiny neck implant is helping some arthritis patients. Here’s how it works  Austin American-Statesman
Colorado doctors perform first ‘game-changing’ thumb arthritis surgery in the western U.S.  UCHealth
The Arthritis Treatments Doctors Turn to Most — and How They Help  Hartford Hospital
Squeezing more from arthritis drugs to help patients live better | Horizon Magazine  research-and-innovation.ec.europa.eu

Common Rheumatological Symptoms

Joint Pain (Arthralgia) — Persistent discomfort or soreness in one or more joints caused by inflammation, wear and tear, or underlying autoimmune responses.
Morning Stiffness — Reduced joint mobility and tightness upon waking, often lasting over 30 to 60 minutes in inflammatory conditions like rheumatoid arthritis.
Joint Swelling and Edema — Visible enlargement of affected joints resulting from fluid accumulation in the synovial membrane and inflamed surrounding tissue.
Localized Warmth and Redness — Elevated temperature and erythema skin discoloration surrounding inflamed joints due to increased blood flow from localized inflammation.
Systemic Fatigue — Overwhelming exhaustion and lack of energy caused by ongoing chronic inflammatory cytokine activity throughout the body.
Raynaud's Phenomenon — Temporary color changes in fingers or toes turning white, blue, and red in response to cold or stress due to vascular spasms.
Malar or Butterfly Rash — Red or purplish facial rash spanning across the bridge of the nose and cheeks, classically associated with systemic lupus erythematosus.

Milestones in Rheumatology History

c. 400 BC: Hippocratic Corpus Coining — Hippocrates uses the term "rheuma" to describe body humors flowing into joints, establishing the early classical concept of joint inflammation.
1592: Formal Definition of Rheumatism — French physician Guillaume de Baillou introduces the modern term "rheumatism" to distinguish systemic acute arthritis from localized gout.
1800: Clinical Description of Rheumatoid Arthritis — Augustin Jacob Landré-Beauvais publishes the first detailed clinical description separating rheumatoid arthritis from gout, calling it "asthenic gout."
1859: Naming of Rheumatoid Arthritis — Sir Alfred Baring Garrod formally coins the term "rheumatoid arthritis" to clearly differentiate the inflammatory autoimmune condition from osteoarthritis and gout.
1940: Discovery of the Rheumatoid Factor — Erik Waaler discovers autoantibodies in the blood of patients with rheumatoid arthritis, laying the groundwork for serological autoimmune diagnostics.
1948: Introduction of Corticosteroid Therapy — Philip Hench and Edward Kendall demonstrate the dramatic anti-inflammatory effects of Compound E (cortisone) in treating rheumatoid arthritis, earning the Nobel Prize.
1998: Emergence of Biologic DMARDs — The FDA approves the first TNF-alpha inhibitors, ushering in the modern era of targeted biologic therapies for autoimmune rheumatic diseases.

Current Trends in Rheumatology Research

Chimeric Antigen Receptor (CAR) T-Cell Reset Therapy — Investigating engineered cellular therapies to achieve drug-free, durable clinical remissions by completely depleting pathogenic autoantibodies in severe refractory lupus and systemic sclerosis.
Selective TYK2 and Oral JAK Pathway Inhibition — Developing highly targeted, small-molecule oral inhibitors like deucravacitinib that disrupt specific cytokine signaling pathways while minimizing broader off-target side effects.
Targeted Pathogenic T-Cell and B-Cell Depletion — Evaluating novel biologics, such as rosnilimab and ianalumab, designed to selectively deplete overactive immune cell subpopulations involved in rheumatoid arthritis and Sjögren's disease.
Biomarker-Driven Precision Medicine — Utilizing pharmacogenomics and molecular biomarkers to predict individualized therapeutic responses and match systemic autoimmune conditions to specific biological mechanisms.
Subclinical Interception and Disease Prevention — Identifying seropositive individuals early using high-risk autoantibody profiles to initiate preventive targeted therapies before irreversible joint damage occurs.
Artificial Intelligence and Predictive Disease Modeling — Deploying machine learning algorithms across electronic health records and imaging modalities to forecast inflammatory flares and refine diagnostic accuracy.