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    Amazon - Reddit
    Welcome to /r/Amazon Please try to focus on community-oriented content, such as news and discussions, instead of individual-oriented content. If you have questions or need help, please use the stickied help thread. Please follow reddiquette and read the subreddit rules before posting here.

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    Your home for all-things Amazon Luna on reddit including games, news and more discussion! Actively maintained and moderated with love. We're also the home of the biggest and most active Cloud Gaming discord community in partnership with r/CloudGaming! Please join/subscribe and support our growing community.

    Good alternatives to amazon? : r/amazonprime - Reddit
    Amazon delivers stuff in a few days, 90% within a week. eBay, on the other hand, can take 3+ months to deliver, and the delivery companies sucks a lot, as they never truly attempt to deliver the package and make me go pick it up some far place that work on really bad hours, usually crowded with people.

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    Started at Amazon FC this week and wondering when is the pay will get deposited in my bank? It says Friday (which is today ) Does it takes couple days before you get your money ?

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    Community for Amazon employees across the network. Fulfillment Centers, Sort Centers, Delivery Stations, etc. Welcome.

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    This is a community to share and post deals you can find on Amazon. Hopefully you can also find a deal to save a few bucks.

    Is there a way to get to Amazon's US-based Customer Service?
    13 votes, 29 comments. true If I need to talk to someone from the US, what is the fastest way to get in touch with their US support? Anyone found a way or is it just saying "I need to speak to your supervisor" when you talk to the outsourced customer service? Share Add a Comment Sort by: Best Open comment sort options Best Top New Controversial Old Q&A grandma- •

    Scary mail from ofm@amazon.com? : r/amazonprime - Reddit
    Why is Amazon blatantly lying about damaged or used goods when the items I sent back were still sealed in original manufacturers packaging? And the end of the email they specifically said " However, the number of refunds for items received in a damaged condition in your account exceed the expectation." Damaged? These items were factory sealed!

    Unrecognized Amazon Prime charge on credit card - Reddit
    CC company will say Amazon needs to fix the problem and Amazon will say credit card needs fix. I ended up canceling my credit card and Amazon account for good. Also, when I was trying to figure out what was going on I found out there were some law firms putting together a class action lawsuit over this issue.

     

     

     

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    Common Rheumatological Symptoms
    • Joint Pain (Arthralgia) — Persistent discomfort or soreness in one or more joints caused by inflammation, wear and tear, or underlying autoimmune responses.
    • Morning Stiffness — Reduced joint mobility and tightness upon waking, often lasting over 30 to 60 minutes in inflammatory conditions like rheumatoid arthritis.
    • Joint Swelling and Edema — Visible enlargement of affected joints resulting from fluid accumulation in the synovial membrane and inflamed surrounding tissue.
    • Localized Warmth and Redness — Elevated temperature and erythema skin discoloration surrounding inflamed joints due to increased blood flow from localized inflammation.
    • Systemic Fatigue — Overwhelming exhaustion and lack of energy caused by ongoing chronic inflammatory cytokine activity throughout the body.
    • Raynaud's Phenomenon — Temporary color changes in fingers or toes turning white, blue, and red in response to cold or stress due to vascular spasms.
    • Malar or Butterfly Rash — Red or purplish facial rash spanning across the bridge of the nose and cheeks, classically associated with systemic lupus erythematosus.

      

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    Milestones in Rheumatology History
    • c. 400 BC: Hippocratic Corpus Coining — Hippocrates uses the term "rheuma" to describe body humors flowing into joints, establishing the early classical concept of joint inflammation.
    • 1592: Formal Definition of Rheumatism — French physician Guillaume de Baillou introduces the modern term "rheumatism" to distinguish systemic acute arthritis from localized gout.
    • 1800: Clinical Description of Rheumatoid Arthritis — Augustin Jacob Landré-Beauvais publishes the first detailed clinical description separating rheumatoid arthritis from gout, calling it "asthenic gout."
    • 1859: Naming of Rheumatoid Arthritis — Sir Alfred Baring Garrod formally coins the term "rheumatoid arthritis" to clearly differentiate the inflammatory autoimmune condition from osteoarthritis and gout.
    • 1940: Discovery of the Rheumatoid Factor — Erik Waaler discovers autoantibodies in the blood of patients with rheumatoid arthritis, laying the groundwork for serological autoimmune diagnostics.
    • 1948: Introduction of Corticosteroid Therapy — Philip Hench and Edward Kendall demonstrate the dramatic anti-inflammatory effects of Compound E (cortisone) in treating rheumatoid arthritis, earning the Nobel Prize.
    • 1998: Emergence of Biologic DMARDs — The FDA approves the first TNF-alpha inhibitors, ushering in the modern era of targeted biologic therapies for autoimmune rheumatic diseases.
    Current Trends in Rheumatology Research
    • Chimeric Antigen Receptor (CAR) T-Cell Reset Therapy — Investigating engineered cellular therapies to achieve drug-free, durable clinical remissions by completely depleting pathogenic autoantibodies in severe refractory lupus and systemic sclerosis.
    • Selective TYK2 and Oral JAK Pathway Inhibition — Developing highly targeted, small-molecule oral inhibitors like deucravacitinib that disrupt specific cytokine signaling pathways while minimizing broader off-target side effects.
    • Targeted Pathogenic T-Cell and B-Cell Depletion — Evaluating novel biologics, such as rosnilimab and ianalumab, designed to selectively deplete overactive immune cell subpopulations involved in rheumatoid arthritis and Sjögren's disease.
    • Biomarker-Driven Precision Medicine — Utilizing pharmacogenomics and molecular biomarkers to predict individualized therapeutic responses and match systemic autoimmune conditions to specific biological mechanisms.
    • Subclinical Interception and Disease Prevention — Identifying seropositive individuals early using high-risk autoantibody profiles to initiate preventive targeted therapies before irreversible joint damage occurs.
    • Artificial Intelligence and Predictive Disease Modeling — Deploying machine learning algorithms across electronic health records and imaging modalities to forecast inflammatory flares and refine diagnostic accuracy.

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