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            * Rheumatology101 SEARCH *

                *Filter: "Vasculitis"

      

    Vasculitis - Symptoms and causes - Mayo Clinic
    People who have conditions in which their immune systems attack their own bodies by mistake may be at higher risk of vasculitis. These conditions include lupus, rheumatoid arthritis and scleroderma.

    Vasculitis: Symptoms, Types & Treatment - Cleveland Clinic
    Vasculitis is an autoimmune disease that causes inflammation in your blood vessels. The swelling makes it hard for blood to flow through your affected vessels, which can cause organ and tissue damage.

    Vasculitis - Wikipedia
    Medium vessel vasculitis (MVV) is a type of vasculitis that mostly affects the medium arteries, which are the major arteries that supply the viscera and their branches.

    Types of Vasculitis : Johns Hopkins Vasculitis Center
    There are approximately 20 different disorders that are classified as “vasculitis”. “ Angiitis ” and “ Arteritis ” are both synonyms for vasculitis, literally meaning “inflammation within blood vessels” or “inflammation in arteries.”

    Vasculitis: Types, Symptoms, Causes, Diagnosis, Treatment and More - Health
    Vasculitis happens when your immune system mistakenly attacks your blood vessels, viewing them as foreign invaders. This leads to inflammation, causing your vessels to become narrow and weak.

    Vasculitis - Diagnosis and treatment - Mayo Clinic
    A corticosteroid medicine, such as prednisone (Rayos), is the most common type of medicine prescribed to control the inflammation of vasculitis. Corticosteroids can have bad side effects.

    Symptoms of Vasculitis - Johns Hopkins Vasculitis Center
    The term “vasculitis” refers to a group of inflammatory diseases that cause inflammation centered in the wall of blood vessels. This vascular inflammation ultimately leads to damage and dysfunction of the organs that contain the affected vessels.

    Vasculitis - NHS
    Vasculitis can range from a minor problem that just affects the skin, to a more serious illness that causes problems with organs like the heart or kidneys. There are many types of vasculitis.

    Vasculitis: 10 Common Signs – and When to See a Doctor
    Vasculitis is a rare but serious group of autoimmune conditions characterised by inflammation of the blood vessels. When your blood vessels become inflamed, they can thicken, narrow, or scar, which restricts vital blood flow to your organs and tissues.

    General Vasculitis
    Vasculitis is a general term that refers to inflammation of the blood vessels. It is used to describe a family of nearly 20 rare diseases, characterized by narrowing, weakening or scarring of the blood vessels, which can restrict blood flow and damage vital organs and tissues.

     

     

     

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    Common Rheumatological Symptoms
    • Joint Pain (Arthralgia) — Persistent discomfort or soreness in one or more joints caused by inflammation, wear and tear, or underlying autoimmune responses.
    • Morning Stiffness — Reduced joint mobility and tightness upon waking, often lasting over 30 to 60 minutes in inflammatory conditions like rheumatoid arthritis.
    • Joint Swelling and Edema — Visible enlargement of affected joints resulting from fluid accumulation in the synovial membrane and inflamed surrounding tissue.
    • Localized Warmth and Redness — Elevated temperature and erythema skin discoloration surrounding inflamed joints due to increased blood flow from localized inflammation.
    • Systemic Fatigue — Overwhelming exhaustion and lack of energy caused by ongoing chronic inflammatory cytokine activity throughout the body.
    • Raynaud's Phenomenon — Temporary color changes in fingers or toes turning white, blue, and red in response to cold or stress due to vascular spasms.
    • Malar or Butterfly Rash — Red or purplish facial rash spanning across the bridge of the nose and cheeks, classically associated with systemic lupus erythematosus.

      

    * Useful Government Health Sites:                               
    Milestones in Rheumatology History
    • c. 400 BC: Hippocratic Corpus Coining — Hippocrates uses the term "rheuma" to describe body humors flowing into joints, establishing the early classical concept of joint inflammation.
    • 1592: Formal Definition of Rheumatism — French physician Guillaume de Baillou introduces the modern term "rheumatism" to distinguish systemic acute arthritis from localized gout.
    • 1800: Clinical Description of Rheumatoid Arthritis — Augustin Jacob Landré-Beauvais publishes the first detailed clinical description separating rheumatoid arthritis from gout, calling it "asthenic gout."
    • 1859: Naming of Rheumatoid Arthritis — Sir Alfred Baring Garrod formally coins the term "rheumatoid arthritis" to clearly differentiate the inflammatory autoimmune condition from osteoarthritis and gout.
    • 1940: Discovery of the Rheumatoid Factor — Erik Waaler discovers autoantibodies in the blood of patients with rheumatoid arthritis, laying the groundwork for serological autoimmune diagnostics.
    • 1948: Introduction of Corticosteroid Therapy — Philip Hench and Edward Kendall demonstrate the dramatic anti-inflammatory effects of Compound E (cortisone) in treating rheumatoid arthritis, earning the Nobel Prize.
    • 1998: Emergence of Biologic DMARDs — The FDA approves the first TNF-alpha inhibitors, ushering in the modern era of targeted biologic therapies for autoimmune rheumatic diseases.
    Current Trends in Rheumatology Research
    • Chimeric Antigen Receptor (CAR) T-Cell Reset Therapy — Investigating engineered cellular therapies to achieve drug-free, durable clinical remissions by completely depleting pathogenic autoantibodies in severe refractory lupus and systemic sclerosis.
    • Selective TYK2 and Oral JAK Pathway Inhibition — Developing highly targeted, small-molecule oral inhibitors like deucravacitinib that disrupt specific cytokine signaling pathways while minimizing broader off-target side effects.
    • Targeted Pathogenic T-Cell and B-Cell Depletion — Evaluating novel biologics, such as rosnilimab and ianalumab, designed to selectively deplete overactive immune cell subpopulations involved in rheumatoid arthritis and Sjögren's disease.
    • Biomarker-Driven Precision Medicine — Utilizing pharmacogenomics and molecular biomarkers to predict individualized therapeutic responses and match systemic autoimmune conditions to specific biological mechanisms.
    • Subclinical Interception and Disease Prevention — Identifying seropositive individuals early using high-risk autoantibody profiles to initiate preventive targeted therapies before irreversible joint damage occurs.
    • Artificial Intelligence and Predictive Disease Modeling — Deploying machine learning algorithms across electronic health records and imaging modalities to forecast inflammatory flares and refine diagnostic accuracy.

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